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GitHub
AI Model·2024
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ESM (Biohub/esm)

Biohub (EvolutionaryScale Team)

Provides code, pretrained weights, and tooling for protein language models and structure prediction — including ESMC, ESMFold2, sparse autoencoders (SAEs), and the ESM Atlas. Includes model checkpoints, tutorials, Hugging Face & Biohub integration, and an MIT license.

#foundation-model#transformers#huggingface#pytorch#biology+4
GitHub
AI Agent·2025
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Biomni: A General-Purpose Biomedical AI Agent

Kexin Huang, Serena Zhang +8

Autonomously executes diverse biomedical research tasks by combining LLM reasoning, retrieval-augmented planning, and code-based execution. Includes a web UI and Gradio demo, a curated Know‑How library, MCP integration, and a biology-tailored reasoning model (Biomni‑R0).

#ai-agent#biology#genomics#drug-discovery#agent-skills+7
Hugging Face
AI Dataset·2026
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Anthropic/BioMysteryBench-full

Anthropic, Hugging Face

A collection of biology-focused 'mystery' tasks for benchmarking model performance on biomedical reasoning, evidence synthesis, and problem solving; curated by Anthropic and hosted on Hugging Face, designed for granular evaluation of scientific decision-making.

#anthropic#huggingface#evaluation#benchmarks#reasoning+1
Hugging Face
AI Dataset·2026
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Carbon Pretraining Corpus

HuggingFaceBio, GenerTeam +1

Provides 173M DNA/RNA sequences (≈1.1 trillion nucleotides) assembled specifically for pretraining genomic foundation models. Includes eukaryote, prokaryote, and mRNA configs plus a 10B‑token eukaryote subset for faster experiments; formatted for streaming and tokenized with Carbon's 6‑mer setup.

#huggingface#genomics#biology#foundation-model#transformers
AI Dataset·2026
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K12-KGraph: A Curriculum-Aligned Knowledge Graph for Benchmarking and Training Educational LLMs

Hao Liang, Qihan Lin +6

Provides a curriculum-aligned knowledge graph extracted from Chinese K–12 textbooks and accompanying benchmarks and training data to evaluate and train educational LLMs. Releases a 23,640-question multi-select benchmark and a 7,335-sample graph-guided training corpus with multimodal VQA pairs and the full construction pipeline.

#benchmark#multimodal#vision#llm#nlp+6
Hugging Face
AI Dataset·2026
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Open-MM-RL

Shukla, Chinmayee, Patil, Saurabh +21

Multimodal STEM problem set for verifiable, answer-supervised training and RL: contains single-image, multi-panel, and multi-image PhD-level questions across physics, math, chemistry and biology. Each example has a deterministic ground-truth answer, enabling reward modeling and automated evaluation.

#multimodal#RL#science#physics#math+5
Hugging Face
AI Dataset·2026
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HelioAI DeepReason 462×105M (Mythos V2 Distill)

HelioAI Labs

Provides 462 unrestricted long-form chain-of-thought reasoning traces distilled from the full Mythos V2 model (≈104.7M characters); intended for long-context evaluation, trace analysis and process-level supervision. License unknown—verify before reuse.

#huggingface#llm#evaluation#security#biology
Hugging Face
AI Dataset·2026
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Emerald Bay

Tahoe Therapeutics, tahoebio +1

Provides per-cell transcriptomes and five-day drug-sensitivity readouts for 1.83M single cells across 52 cancer cell lines and 91 drug conditions, with raw counts plus gene, cell-line, drug, and summary metadata for modeling drug response and context-dependent gene function.

#biology#genomics#drug-discovery#chemistry#huggingface+2
Hugging Face
AI Model·2026
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Qwythos-9B-Claude-Mythos-5-1M-GGUF

Empero (empero-ai), Alibaba Qwen team (Qwen3.5-9B base)

Provides GGUF-quantized weights and runtime assets for running the Qwythos-9B reasoning LLM locally via llama.cpp and compatible runtimes. Key features include 1,048,576-token YaRN long-context, native function-calling, multimodal image input (requires mmproj), and multiple quantization/MTP variants tuned for different size/quality tradeoffs.

#qwen#huggingface#llm#multimodal#vision+3
Hugging Face
AI Model·2026
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Qwythos-9B

Empero, Alibaba / Qwen team

A 9B reasoning LLM fine-tuned from Qwen3.5 that ships with a 1,048,576-token context, native function-calling and tool-use, and notable benchmark gains (+34 MMLU, +30 gsm8k-strict).

#qwen#llm#transformers#huggingface#vllm+6
Hugging Face
AI Dataset·2026
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FineBooks BHL IMPACT Ground Truth

finebooks (Hugging Face), IMPACT Centre of Competence +1

Provides 2,165 historical natural-history page scans paired with ~99.95% expert transcriptions and pixel-aligned PAGE XML layout ground truth for OCR and layout evaluation; multilingual (EN/FR/DE/LA), CC-BY 3.0.

#ocr#vision#multilingual#benchmark#huggingface+4
Machine Learning Foundation Papers·2026
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Accurate, Interdisciplinary and Transparent Structure-property Understanding with Deep Native Structural Reasoning

Chen Tang, Yizhou Wang +27

Performs native structural reasoning for proteins, small molecules and inorganic crystals by tokenizing coordinates, topologies and periodic connectivities into a unified structure-aware vocabulary. Treats structural tokens as addressable evidence to produce interpretable prediction traces and improves accuracy across biology, chemistry and materials benchmarks.

#foundation-model#multimodal#chemistry#biology#science+6
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